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By Bethel Solomons (Auth.)

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KERATOSIS PALMARIS ET PLANTARIS (Tylosis Palmaris et Plantaris) T h i s d i s o r d e r is c h a r a c t e r i z e d b y g r o s s t h i c k e n i n g of t h e p a l m s a n d soles, w h i c h m a y a p p e a r s h o r t l y a f t e r b i r t h , o r a t a n y t i m e u p t o t h e a g e of 1 5 . I t is d i r e c t l y t r a n s m i t t e d , b u t a n u m b e r of s o l i t a r y c a s e s a r e recorded. C l i n i c a l F e a t u r e s . — S k i n becomes yellow, thick, a n d h o r n y or w a r t y , a n d m a y i n v o l v e b a c k of h a n d s a n d feet.

F O O D S . — H y p e r s e n s i t i v i t y t o shell-fish, m u s h r o o m s , s t r a w b e r r i e s , etc. 2. D R U G S . — H y p e r s e n s i t i v i t y t o p e n i c i l l i n , s u l p h o n a m i d e s , b a r biturates, etc. 38 C O N G E N I T A L D I S E A S E S Poikiloderma Congenitale—Clinical Features, continued. normal. Sometimes cranial bone abnormalities occur. teeth m a y be present. Defective CONGENITAL TELANGIECTATIC ERYTHEMA RESEMBLING LUPUS ERYTHEMATOSUS IN DWARFS T h i s r a r e d i s o r d e r is c h a r a c t e r i z e d b y l u p u s e r y t h e m a t o s u s - l i k e lesions o n t h e b u t t e r f l y a r e a of t h e face, w i t h a b u l l o u s e r u p t i o n o n t h e l o w e r lip.

T h e c o n d i t i o n is m a i n l y confined t o t h e U n i t e d S t a t e s . 10. R I L E Y - D A Y S Y N D R O M E . — B l o t c h y e r y t h e m a t o u s m a c u l e s o n t h e face, chiefly s e e n i n J e w s , a c c o m p a n i e d b y cold m o i s t s k i n , a n d m e n t a l r e t a r d a t i o n , fits, h y p e r i d r o s i s , h y p e r t e n s i o n , d e f e c t i v e l a c r i m a t i o n , c o r n e a l u l c e r s , r e l a t i v e indifference t o p a i n , a n d other symptoms.

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