By Esen Özkaya, Kurtuluş Didem Yazganoğlu
Adverse cutaneous drug reactions (ACDR) are one of the such a lot common occasions in sufferers receiving drug remedy. Cardiovascular (CV) medicinal drugs are a major team of gear with capability chance of constructing ACDR specifically in aged as advertising of extra new medicinal drugs and their prescription proceed to extend. even though, like with such a lot different medicines the precise prevalence of cutaneous negative effects from CV medicines is tough to estimate because of sporadic reporting. furthermore, a competent designation of a definite drug because the explanation for a definite form of response can infrequently be made. except the well known angioedema/urticaria from ACE inhibitors, lichen planus / lichenoid response from beta adrenergic blockers and photosensitivity from thiazid diuretics, ACDR from CV medications will be obvious in a large spectrum extending to infrequent yet life-threatening stipulations similar to erythroderma, Stevens-Johnson syndrome, poisonous epidermal necrolysis or drug allergic reaction syndrome. during this accomplished evaluation, the suggested forms of ACDR to CV medicines could be mentioned based on drug classification and the kind of dermatologic response with certain emphasize on cross-reactions and the function of patch checking out in diagnosis.
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Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
Opposed cutaneous drug reactions (ACDR) are one of the such a lot common occasions in sufferers receiving drug remedy. Cardiovascular (CV) medicinal drugs are an enormous workforce of gear with capability hazard of constructing ACDR in particular in aged as advertising of extra new medications and their prescription proceed to extend.
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Additional info for Adverse Cutaneous Drug Reactions to Cardiovascular Drugs
Withdrawal of the causative drug and treatment with topical corticosteroids will usually result in the recovery of the lesions. Fig. 24 Fixed drug eruption: solitary, ovalshaped, reddish-colored plaque on the trunk Fig. 25 Fixed drug eruption: multiple, round- to oval-shaped, dusky redcolored plaques on the trunk 18 Fig. 26 Fixed drug eruption: multiple, round- to oval-shaped, bright-redcolored plaques on the trunk Fig. 27 Fixed drug eruption: round- to ovalshaped, dusky purple-colored plaques on the dorsum of the hand surmounted by bullae 1 General Aspects of Adverse Cutaneous Drug Reactions Characteristic Features of Adverse Cutaneous Drug Reactions Fig.
Phenytoin when used as antiepileptic drug is frequently associated with DHS/ DRESS. Withdrawal of the offending drug and treatment with systemic corticosteroids are usually effective. Lymphomatoid Drug Eruption/Pseudolymphoma Syndrome Lymphomatoid drug eruption or PLS and DHS show some similar clinical and histological findings. Like DHS, PLS is another life-threatening reaction that presents with fever, generalized skin eruption, lymphadenopathy, and internal organ involvement. It may take a prolonged course even after the cessation of causative agents .
10 Eczematous drug eruption on the back skin and the outer part of the upper extremity showing widespread erythematous, edematous, and vesicular lesions Fig. 11 Eczematous drug eruption on the flexural part of the upper extremity and on the trunk showing erythematous, edematous, and vesicular lesions 1 General Aspects of Adverse Cutaneous Drug Reactions Characteristic Features of Adverse Cutaneous Drug Reactions Fig. 12 Eczematous drug eruption on the upper arm with erythematous, edematous, and vesicular lesions Fig.