By Miranda A. Farage, Kenneth W. Miller, Nancy Fugate Woods, Howard I. Maibach
An period of worldwide inhabitants getting older is upon us. through 2030, one in 8 humans could be over age sixty five. given that ladies in most cases outlast males, the well-being and welfare of postmenopausal girls becomes an important public future health quandary. This booklet bargains a accomplished overview of the existence adjustments linked to menopause, either on the dermatological and physiological point (e.g., hormonal, immunological) and on the subcellular point. It seriously examines the dermatological, organic, and medical demanding situations to postmenopausal future health and health and the present and rising healing interventions. The authors suggest a holistic technique, emphasizing the necessity to view the menopause as a lifestyles transition with numerous aspects instead of as a sequence of particular health conditions to be controlled. Our objective is to provide a accomplished source to the researchers, clinicians, physicians, and supporting professions whose project is to advertise the health and wellbeing and wellbeing and fitness of ladies round the world.
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Extra info for Skin, Mucosa and Menopause: Management of Clinical Issues
Sample text
2 Progesterone Given that progesterone is produced by of the corpus luteum, its levels decline postmenopaus- ally [39]. During the reproductive years, progesterone protects the endometrium from excess estrogen stimulation by directly regulating estrogen receptors, while exerts a direct intranuclear effect by inhibiting the trophic effects of estrogen on the endometrium [6]. Because circulating levels of estrogen can remain relatively high enough to stimulate the endometrium both pre- and postmenopausally, this unopposed stimulation of the endometrium just prior to and after menopause may explain the higher risk of endometrial hyperplasia and cancer reported during this time.
11. MacLean AB, Nicol LA, Hodgins MB. Immunohistochemical localization of estrogen receptors in the vulva and vagina. J Reprod Med. 1990;35(11):1015–6. 12. Danforth DN, Veis A, Breen M, Weinstein HG, Buckingham JC, Manalo P. The effect of pregnancy and labor on the human cervix: changes in collagen, glycoproteins, and glycosaminoglycans. Am J Obstet Gynecol. 1974;120(5):641–51. 13. Grosman N, Hvidberg E, Schou J. The effect of estrogenic treatment on the acid mucopolysaccharide pattern in skin of mice.
Histologically, severe degenera- Wound Healing in Postmenopause Healing of the skin is first characterized by an inflammation, followed by the formation of granulation tissue, after reepithelialization, and finally, the remodeling of tissues. Delayed wound healing usually occurs in the elderly, and estrogen has been shown to play a crucial role in wound healing [3]. Elastase is capable of degrading a wide range of functional and structural proteins, such as proteoglycans, fibronectin, and collagen.