By Matt Kalaycio
The Cleveland hospital beginning, OH. textual content covers information regarding new biologic treatments and gives the health care provider with sensible facts for treating sufferers with leukemia. Discusses such remedies as arsenic trioxide, P-glycoprotein inhibitors, and interleukins. additionally covers genetic code changes. DNLM: Leukemia, treatment.
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Extra resources for Biologic Therapy of Leukemia
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Comparison of autologous and allogeneic bone marrow transplantation for treatment of high-risk refractory acute lymphoblastic leukemia. N Engl J Med 1987;317:461–467. 10. Weisdorf D, Nesbit M, Ramsay N, et al. Allogeneic bone marrow transplantation for acute lymphoblastic leukemia in remission: prolonged survival associated with acute graft-versushost disease. J Clin Oncol 1987;5:1348–1355. 11. Doney K, Fisher L, Appelbaum F, et al. Treatment of adult acute lymphoblastic leukemia with allogeneic bone marrow transplantation.
Despite early prophylaxis against infectious diseases with cotrimoxazole and famciclovir, 27% of patients experienced grade 3–5 infections, most of which were pneumonias. Hematologic toxicity was also noted, although difficulties emerged as the investigators tried to distinguish toxicity from the hematopoietic failure induced by the leukemia before treatment. Grade 3–4 anemia occurred in 47%, neutropenia in 70%, and thrombocytopenia in 52% of patients. Within 4 mo, most patients improved their blood cell counts.
Blood 1995;85:3302–3312. 27. Nieda M, Nicol A, Kikuchi A, et al. Dendritic cells stimulate the expansion of bcr-abl specific CD8+ T cells with cytotoxic activity against leukemic cells from patients with chronic myeloid leukemia. Blood 1998;91:977–983. 28. Krijanovski O, Hill G, Cooke K, et al. Keratinocyte growth factor separates graft-versus-leukemia effects from graft-versus-host disease. Blood 1999;94:825–831. 29. Jiang Y, Barrett A, Goldman J, Mavroudis D. Association of natural killer cell immune recovery with a graft-versus-leukemia effect independent of graft-versus-host disease following allogeneic bone marrow transplantation.