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By H. C. Dung, Curtis P. Clogston, Joeming W Dunn

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Mild acne: - Topical treatment: antibiotic/BPO, retinoid/BPO, retinoid/ antibiotic, BPO, retinoids, AZA. Moderate to severe papulopustular acne: - Oral antibiotics: doxycyline (first choice) until clinical response and max up to 12 weeks. - Hormonal treatment: for females only, when indicated. - Combine with topical treatment. Severe cystic acne: - Oral antibiotics: doxycyline (first choice) for up to 12 weeks. - Combine with topical treatment. 5 mg/kg/day up to a cumulative dose of 120-150 mg/kg/day, or until clinical response.

D. Katsambas et al. 1007/978-3-662-45139-7_2, © Springer-Verlag Berlin Heidelberg 2015 19 20 100 % of these persons will present with AK, of the remaining people who had been exposed to the sun, it is unpredictable what percentage will develop AK. g. g. Italy, France, Spain) and so on. Prevalence studies show clear differences depending on the country, being higher when closer to the equator. 2 % respectively in patients with 70 years old (Guidelines ILDS 2015). In sum, despite its high prevalence large-scale records to estimate the exact incidence and prevalence in our environment have not been carried out.

Metformin, a biguanide, is the most commonly used insulin sensitizer for the treatment of PCOS. It inhibits hepatic glucose production and increases peripheral insulin sensitivity but does not cause hypoglycemia. Halborne et al. reported in 52 women with PCOS similar self-assessed improvement in mild acne with metformin 1,500 mg daily for 14 months compared to oral contraceptive 35 μg ethinyl estradiol plus 2 mg cyproterone acetate, with no changes in sebum excretion rates. Kolodziejczyk et al.

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