By Timothy S. Tracy, Richard L. Kingston
Herbal items: Toxicology and scientific Pharmacology, moment version builds at the informative origin laid by way of its predecessor. This absolutely revised and extended moment variation boasts greater than two hundred new references that rfile efficacy stories and antagonistic results and 4 new chapters dedicated to nutritional items. Practitioners and researchers will locate that this quantity is a accomplished source for aim scientific information regarding the capability makes use of, efficacy, and security of natural medicinal drugs. The authors realize that almost all of obtainable details on supplements is sometimes supplied via vendors and designed to promote a product instead of objectively tell shoppers; hence, the emphasis all through is on info no longer on hand from the other resource. just like the 1st version, this quantity is predicated on unique reports released in peer-reviewed journals, in addition to meta-analyses, systematic experiences, and different top of the range checks by means of well-known specialists.
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Additional info for Herbal Products: Toxicology and Clinical Pharmacology
Example text
Ann Intern Med 1996;125:940–941. 40. Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos 2002;30:1153–1157. 41. Gurley BJ, Gardner SF, Hubbard MA, et al. In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/ 5 phenotypes. Clin Pharmacol Ther 2005;77:415–426. 42. FDA Advisory on Kava potential for liver toxicity from FDA Center for Food Safety and Applied Nutrition.
A liver transplant was performed and the individual survived (33). A healthy 14-year-old adolescent girl developed nausea, vomiting, general malaise, and weight loss. Several days later she became icteric and was admitted to hospital with acute hepatitis. Drug history revealed no alcohol use; two kava products and occasional ibuprofen had been used over the preceding 4 months. The packaging of the kava products was unavailable for identification purposes. Liver biopsy revealed active fulminant hepatitis with extensive necrosis and tests for viral hepatitis were negative.
Vahedi K, Domigo V, Amarenco P, Bousser MG. Ischaemic stroke in a sportsman who consumed MaHuang extract and creatine monohydrate for body building. J Neurol Neurosurg Psychiatry 2000;68(1):112–113. 95. du Boisgueheneuc F, Lannuzel A, Caparros-Lefebvre D, De Broucker T. [Cerebral infarction in a patient consuming MaHuang extract and guarana]. Presse Med 2001;30(4):166–167. 96. Bruno A, Nolte KB, Chapin J. Stroke associated with ephedrine use. Neurology 1993;43(7):1313–1316. 97. Loizou LA, Hamilton JG, Tsementzis SA.