By T. M. Kündig (auth.), Prof. Dr. Günter Burg M.D., PD Dr. Reinhard G. Dummer M.D. (eds.)
Recent growth within the fields of pharmacology and immunology has supplied us with new chances for treating dermatological illnesses. This publication studies crucial immunosuppressive and immunostimulatory medicines and provides valuable, sensible details at the remedy of assorted dermatoses, together with autoimmundiseases, atopic dermatitis, psoriasis, vasculitis, touch dermatitis, pyoderma gangrenosum, infectious ailments, and neoplasms of the outside - specifically, malignant melanoma.
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Extra resources for Strategies for Immunointerventions in Dermatology
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Epidermolysis bullosa acquisita (EBA), a disease resistant to other immunosuppressive agents, is responsive to CsA treatment [49]. The response to CsA in patients with pemphigus and bullous pemphigoid is associated with a decrease in serum titers of autoantibodies and a decrease in immune deposits in the skin. A similar decrease in serum autoantibodies was not noted in EBA [16], and the precise mechanism by which CsA ameliorates EBA is unknown. Alopecia Areata. Hypertrichosis is a common side effect of CsA therapy and thus became of interest in the treatment of alopecia.
IL-2R activation. T cell responses requiring signaling through the TCR-CD3 complex, as in primary and secondary mixed lymphocyte response, MLR and autologous MLR, are sensitive to CsA. CsA also inhibits T cell proliferation induced by mitogenic lectins, superantigens, cross-linking CD2 on the T cell surface, or by the combination of phorbol12-myristate 13-acetate (PMA),an activator of protein kinase C,and the calcium ionophore, ionomycin. Interestingly, each of these CsA-sensitive pathways is associated with an initial rise in intracellular calcium, suggesting that a common intermediate may be the molecular target of this drug.
Van der Bruggen P, Traversari C, Chomez P, Lurquin C, De Plaen E, Van den Eynde B, Knuth A, Boon T (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643-1648 114. Van Pel A, van der Bruggen P, Coulie P, Brichard VG, Lethe B, Van den Eynde B, Uyttenhove C, Renauld JC, Boon T (1995) Genes coding for tumor antigens recognized by cytolytic T lymphocytes. Immunol Rev 145:229-250 115. Varney V, Hamid QA, Gaga M, Ying S, Jacobson M, Frew AJ, Kay AB, Durham SR (1993) Influence of grass pollen immunotherapy on cellular infiltration and cytokine mRNA expression during allergen -induced late phase cutaneous responses.