By Raymond L. Barnhill
An excerpt from "Pathology of Melanocytic Nevi and Malignant cancer, moment Edition", Pathology of Malignant Melanoma offers a hugely functional method of the histopathological analysis of cancer of the outside. Emphasis is put on the differential prognosis of significant different types of traditional cancer, and the booklet additionally discusses strange or infrequent editions which are tricky to acknowledge. This moveable, simple guide addresses epidemiology, standards for prognosis and class of cancer, chance components, and different morphological and cytological editions. greater than 30 easy-to-read tables offer at-a-glance reference and over a hundred complete colour illustrations supplement the text.
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Additional info for Pathology of Malignant Melanoma
Example text
We believe that all such lesions with features of solar intraepidermal melanocytic proliferation (SIMP) should be either adequately sampled or completely removed for full histopathologic examination to exclude melanoma in situ or invasive melanoma. Melanoma in situ may ensue as one begins to observe clustering or intraepidermal nesting of atypical melanocytes, proliferation along adnexal epithelium, and some pagetoid spread. The melanocytes commonly show retraction of cytoplasm and somewhat angulated or slightly spindled nuclei that are pleomorphic and often hyperchromatic.
6). Although there are no quantitative data available on the density of pagetoid spread needed to diagnose TABLE 8 Prevalence of pagetoid melanocytosis in variou melanocytic lesions. Lesioll Percellt Number of cases Melanoma 76 103 pitz tumor 38 47 evi of palms an d oles Pigmented spindle cell nevi Recurrent nevi Vulvar nevi evi of infancy and ch ildhood Ordinary acquired nevi Source: Adapted from Stern and Haupt (1998) (49). "Cases preselected for pagetoid melanoc)'tosis. 6] 20 18 60 80 10 10 5 o 100 100 3" 24 Pathology of Malignant Melanoma FIGURE 6 Pagetoid pattern of melanoma in situ.
B FIGURE 5 Melanoma in situ with pagetoid pattern is the most frequent histomorphologic pattern of intraepidermal melanoma. A, Pagetoid spread of epithelioid cells throughout epidermis. , an imaginary horizontal line linking the most superficial limits of the dermal papillae) provides compelling evidence for melanoma. B, Significant cytologic atypia of melanocytes provides confirmatory evidence for melanoma. 22 Conventional Melanomas 23 to 76% of melanomas in various studies) (46,48) and has been proposed as the major histopathologic criterion for pagetoid or superficial spreading melanoma.