Download Litt's Drug Eruptions and Reactions Manual, 19th Edition by Jerome Z. Litt, Neil Shear PDF

By Jerome Z. Litt, Neil Shear

Nearly 20 years after the 1st Drug Eruptions & Reactions guide was compiled by way of Dr. Litt, this vintage paintings has been built and accelerated into Litt’s D.E.R.M. Relied upon via dermatologists and clinical practitioners across the world for its remarkable sensible specialise in adversarial results and cutaneous reactions, this article is the basic quick-reference device for sufferer care and drug safety.

While a finished photograph is accessible through a subscription to the net database, the guide provides crucial info for fast scientific reference – the exchange names, half-life, identified interactions with different medicines, the being pregnant class into which the drug falls besides as the different types of reactions and the prevalence and variety of reactions suggested for every. The guide additionally deals a brief description of the most typical eruption styles, lists of the medication that reason very important reactions, and a concordance of synonyms, familiar names, and exchange names. even though the handbook has grown from a foundation in dermatology, all general medicines are integrated and all kinds of response past these present in the skin, hair, and nails are recorded.

New this 12 months is a groundbreaking part on category reactions: ten significant periods of common medications (including ACE inhibitors, statins, and tricyclic antidepressants). These are offered in tabular shape, exhibiting at a look which reactions are recognized to take place in all individuals of the category and at which degrees, which happen in a majority, and which take place at major degrees for even a couple of individuals.

No scientific practitioner can have enough money to be with out this priceless software to assist expect, diagnose, and unravel difficulties bobbing up from prescription drugs. preferably practitioners should still avial themselves of either the database and the guide, for his or her diversified purposes.

 

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Additional resources for Litt's Drug Eruptions and Reactions Manual, 19th Edition

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3 hours Clinically important, potentially hazardous interactions with: aminophylline, aspirin, cilostazol, enoximone, fluvoxamine, fondaparinux, inamrinone, milrinone, olprinone, sucralfate Pregnancy category: C Note: Contraindicated in patients with severe hepatic impairment. 0] Proof [derm_#03] by Litt’s Drug Eruptions & Reactions Manual Atrial fibrillation [1] Cardiomyopathy Chest pain Congestive heart failure [1] Heart block Hypotension [1] Myocardial infarction [1] Myocardial toxicity [2] Palpitation (26%) [2] Pericardial effusion Pericarditis Tachycardia [5] Vasodilation Central Nervous System Amnesia Anorexia Chills (<5%) Confusion Depression (<5%) Fever Headache (44%) [9] Nervousness Pain (15%) Paresthesias (7%) Seizures Somnolence Stroke [1] Syncope Vertigo (15%) Neuromuscular/Skeletal Arthralgia (<5%) Asthenia (23%) Back pain (6%) Leg cramps (<5%) Myalgia/Myositis/Myopathy/Myotoxicity (<5%) Gastrointestinal/Hepatic Abdominal pain [3] Diarrhea Dyspepsia Flatulence Gastritis Gastrointestinal bleeding Gastrointestinal ulceration Pancreatitis Vomiting Respiratory Asthma Bronchitis Cough Dyspnea (12%) Eosinophilic pneumonia Flu-like syndrome (<5%) Pleural effusion Pneumonia Pneumonitis Pulmonary fibrosis Pulmonary hypertension Rhinitis Sinusitis Endocrine/Metabolic Dehydration ANASTROZOLE Genitourinary Dysuria Erectile dysfunction [2] Hematuria Renal Renal failure Hematologic Hemorrhage Thrombocytopenia Otic Tinnitus (<5%) Ocular Amblyopia Diplopia Hallucinations, visual [1] Other Adverse effects (<5%) Death [1] ANAKINRA Trade name: Kineret (Amgen) Indications: Rheumatoid arthritis Class: Disease-modulating antirheumatoid drug, Interleukin-1 receptor antagonist (ILIRa) Half-life: 4–6 hours Clinically important, potentially hazardous interactions with: abatacept, adalimumab, certolizumab pegol, etanercept, golimumab, infliximab, lenalidomide, typhoid fever vaccine, yellow fever vaccine Pregnancy category: B Skin Cellulitis [1] Hypersensitivity Lichenoid eruption [1] Central Nervous System Headache (12%) [1] Gastrointestinal/Hepatic Abdominal pain (5%) Diarrhea (8%) Nausea (8%) Respiratory Flu-like syndrome (6%) Sinusitis (7%) Upper respiratory tract infection (4%) [1] Local Injection-site ecchymoses Injection-site edema [1] Injection-site erythema [1] Injection-site inflammation Injection-site pain Injection-site reactions (71%) [18] Other Infection (40%) [4] ANASTROZOLE Trade name: Arimidex (AstraZeneca) Indications: Breast carcinoma (localized – advanced or metastatic) Class: Antineoplastic, Aromatase inhibitor Half-life: 50 hours Clinically important, potentially hazardous interactions with: estradiol, estrogens, tamoxifen Pregnancy category: X Note: Contraindicated in women of premenopausal endocrine status, including pregnant women.

Contraindicated in patients with asthma without use of a long-term asthma control medication. 0] Proof [derm_#03] by Litt’s Drug Eruptions & Reactions Manual ARTEMETHER / LUMEFANTRINE Trade name: Coartem (Novartis) Indications: Acute, uncomplicated malaria infections due to Plasmodium falciparum in patients of 5 kg bodyweight and above Class: Antimalarial Half-life: ~2 hours (artemether); 3–6 days (lumefantrine) Clinically important, potentially hazardous interactions with: amiodarone, amitriptyline, amoxapine, antiretrovirals, arsenic, astemizole, atazanavir, atovaquone / proguanil, azithromycin, ciprofloxacin, citalopram, clomipramine, conivaptan, CYP2D6 substrates, CYP3A4 inhibitors, darunavir, dasatinib, degarelix, delavirdine, disopyramide, dolasetron, duloxetine, flecainide, halofantrine, hormonal contraceptives, imipramine, indinavir, itraconazole, lapatinib, levofloxacin, levomepromazine, lopinavir, mefloquine, moxifloxacin, nelfinavir, norfloxacin, ofloxacin, paroxetine, pazopanib, pimozide, procainamide, quinidine, quinine, risperidone, sotalol, telavancin, telithromycin, terfenadine, tipranavir, venlafaxine, voriconazole, vorinostat, ziprasidone, zuclopenthixol Pregnancy category: C Note: Artemether / Lumefantrine tablets should not be used to treat severe malaria or to prevent malaria.

5% efficient) Clinically important, potentially hazardous interactions with: corticosteroids, immunosuppressive therapies, other vaccines Pregnancy category: D Note: Dr. ’ Note that no number of military personnel was mentioned at this installation, nor did it give any percentages for the reactions reported. 0] Proof [derm_#03] by Litt’s Drug Eruptions & Reactions Manual Oral pemphigus [1] Cardiovascular Flushing Central Nervous System Chills (<1%) [2] Depression [1] Fever (<1%) [3] Guillain–Barre´ syndrome [2] Headache (4–64%) [2] Insomnia Pain [1] Paresthesias [1] Syncope Tremor [1] Vertigo Neuromuscular/Skeletal Arthralgia [4] Asthenia (5–62%) [1] Bone or joint pain [1] Myalgia/Myositis/Myopathy/Myotoxicity (2–72%) [4] Rhabdomyolysis Gastrointestinal/Hepatic Diarrhea (6–8%) Nausea (6%) Respiratory Flu-like syndrome (<1%) [4] Nasopharyngitis (12–15%) Genitourinary Dysmenorrhea (7%) Otic Tinnitus [1] Ocular Chorioretinopathy [1] Eyelid edema [1] Optic neuritis [1] Local Injection-site burning [1] Injection-site edema [5] Injection-site erythema [2] Injection-site hematoma [1] Injection-site hypersensitivity [1] Injection-site induration [1] Injection-site inflammation Injection-site nodules [3] Injection-site numbness [1] Injection-site pain [4] Injection-site pruritus [2] Injection-site reactions [6] Other Allergic reactions [2] Systemic reactions [1] APREPITANT APOMORPHINE Trade names: Apokyn (Ipsen), Uprima (Abbott) Indications: Parkinsonism, erectile dysfunction Class: Dopamine receptor agonist Half-life: 40 minutes Clinically important, potentially hazardous interactions with: 5HT3 antagonists, alcohol, alosetron, antihypertensives, dolasetron, granisetron, levomepromazine, ondansetron, palonosetron, risperidone, vasodilators, zuclopenthixol Pregnancy category: C Note: Apomorphine contains sodium metabisulfite which is capable of causing anaphylactoid reactions in patients with sulfite allergy.

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