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By Susan T. Nedorost

Management of Generalized Dermatitis in medical Practice interprets the mechanisms of dermatitis from easy technological know-how proof to perform established thoughts for scientific care. The position of allergic touch dermatitis in atopic dermatitis is explored extensive. basic care physicians, allergists, and dermatologists will benefit from the clean viewpoint that strikes past therapy with corticosteroids and offers diagnostic and healing algorithms for this advanced condition.

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5. Löffler H, Kampf G, Schmermund D, Maibach HI. How irritant is alcohol? Br J Dermatol. 2007;157(1):74–81. 6. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129(8):1892–908. 7. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

Manuscript in submission. 5. Löffler H, Kampf G, Schmermund D, Maibach HI. How irritant is alcohol? Br J Dermatol. 2007;157(1):74–81. 6. Cork MJ, Danby SG, Vasilopoulos Y, Hadgraft J, Lane ME, Moustafa M, Guy RH, Macgowan AL, Tazi-Ahnini R, Ward SJ. Epidermal barrier dysfunction in atopic dermatitis. J Invest Dermatol. 2009;129(8):1892–908. 7. Hatano Y, Man MQ, Uchida Y, Crumrine D, Scharschmidt TC, Kim EG, Mauro TM, Feingold KR, Elias PM, Holleran WM. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.

Tolerance, danger, and the extended family. Annu Rev Immunol. 1994;12:991–1045 (Volume publication date April 1994). 3. Basketter DA, Kan-King-Yu D, Dierkes P, Jowsey IR. Does irritation potency contribute to the skin sensitization potency of contact allergens? Cutan Ocul Toxicol. 2007;26(4):279–86. Chapter 3 The Role of Irritation in Dermatitis: Implications for Treatment Key Concepts • Barrier dysfunction leads to innate immune response that instructs adaptive response • Emollients dampen innate immune response, possibly increasing risk of malignancy in normal skin • Corticosteroids should not be used long-term to treat irritant dermatitis Definition Irritant dermatitis is the result of chemical or mechanical damage to keratinocytes with inflammatory response mediated by the innate immune response.

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