By Jose I. Suarez
Case Western Reserve Univ., Cleveland, OH. offers an authoritative evaluation of diagnostic, medical, and administration concerns in neurocritical care. deals directions for organizing a neurosciences severe care unit and specializes in either neurologic and neurosurgical stipulations. additionally addresses bioethical concerns. considerable illustrations.
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05) with decreased cell adhesion molecule (E-cadherin, E-catenin, CD44, CD44-v6, and E1 integrin) expression and the degree of depth of invasion and lymph node metastasis. 01) (124). 5. INHERITED ALTERATIONS IN ADHESION MOLECULES – ASSOCIATED WITH INCREASED RISK FOR CERTAIN CARCINOMAS There is abundant evidence in the literature that alteration of adhesion structures accompanies and contributes to the progression of epithelial cancers. It is interesting to note that several inherited mutations that ultimately result in the disruption, attenuation or complete loss of the hemidesmosome structure are associated with increased risk of developing certain types of tumors.
44-52. 31. , Diminished expression of integrin adhesion molecules on human colonic epithelial cells during the benign to malign tumour transformation. Gut, 1992. 33(3): p. 342-6. 32. A. and Sonnenberg, A. Dynamics of the alpha6beta4 Integrin in Keratinocytes. Mol Biol Cell, 2002. 13(11): p. 3845-58. 33. C. Hemidesmosome protein dynamics in live epithelial cells. Cell Motil Cytoskeleton, 2003. 54(2): p. 122-34. 34. , Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line, BMGE-H.
20. , Extracellular matrix receptors and mouse skin carcinogenesis: altered expression linked to appearance of early markers of tumor progression. Cancer Res, 1992. 52(10): p. 2966-76. 21. , Altered surface expression and increased turnover of the alpha6beta4 integrin in an undifferentiated carcinoma. Carcinogenesis, 2000. 21(2): p. 325-30. 22. , Altered expression of alpha 6 integrin subunit in oral squamous cell carcinoma and oral potentially malignant lesions. Oral Oncol, 1998. 34(3): p. 204-10.