By T. L. Diepgen, P. J. Coenraads (auth.), Prof. Lasse Kanerva M.D., Ph.D., Prof. Dr. med. Peter Elsner, Prof. Jan E. Wahlberg M.D., Ph.D., Prof. Howard I. Maibach M.D. (eds.)
Due to alterations in sleek existence, occupational dermatoses are expanding. This thoroughly revised and finished version presents the concise info wanted in facing sufferers within the box of occupational dermatology. It combines a hugely functional method of occupational dermatology with the abilities and examine event of experts in scientific and experimental dermatology. The spectrum of ailments coated during this booklet contains: allergic and irritant dermatitis; touch urticaria; photodermatoses; infectious illnesses; epidermis tumors; systematic reactions as a result of percutaneous absorption; predisposed ailments and occupational pores and skin difficulties. the knowledge urgently wanted for day-by-day sufferer administration is equipped as quickly reference via concise tables, algorithms, and figures on easy methods to optimise the diagnostic systems for top of the range care. This e-book will turn out of serious curiosity to all who're taken with treating sufferers with occupational epidermis ailments.
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1998) (Fig. 1). Patients with no active signs of eczema had anormal barrier function and intermediate values of ceramides and cholesterol when compared with normal subjects and AD patients with active lesions. Depletion of lipids is considered a fundamental mechanism in barrier damage. Investigating the ultrastructural changes of epidermal lipids resulting from the topical application of sodium lauryl sulfate (SLS), absolute acetone, and glycolic acid, Fartasch demonstrated that different irritants induce distinct and characteristic alterations in skin lipids, reflecting the specific interaction with the epidermal permeability barrier (Fartasch 1997; Fartasch et al.
1989; Elias and Menon 1991). Removal of L. Kanerva et al. ), Condensed Handbook of Occupational Dermatology © Springer-Verlag Berlin . Heidelberg 2004 3 S. Seidenari et aI. 38 lipids from the SC by solvent extraction leads to a pronounced increase in TEWL, expressing a defect in the integrity of skin function and also representing a stimulus to barrier repair and increased synthesis of lipids by keratinocytes (Grubauer et al. 1989). The sequence of metabolic and subcellular events leading to recovery after acute barrier perturbation consists in a rapid secretion of preformed lamellar bodies by stratum granulosum, and an increase in lipid synthesis leading to further secretion of new lamellar bodies with reconstitution of SC intercellular lamellar bilayers (Elias and Feingold 1992).
Many cases of intoxication Systemic Toxicity 27 have been reported, usually after accidental ingestion by children (Skoglund et al. 1977; Kopelman 1990). Cosmetic Agents Henna dye is used on nails, skin and hair by married women in the Islamie community and consists of the dried leaves of Lawsonia alba (coloring matter is lawsone, a hydroxynaphthoquinone). Sudanese women mix a "black powder" (p-phenylenediamine) with henna to accelerate the fixing; however, this combination is particularly toxie, and over 20 cases of such toxicity, some fatal, have been reported.