By Christos C. Zouboulis
Dermatological learn has skilled a quick improvement within the final twenty years, notwithstanding, it has hardly involved in the endocrine features of the outside. just a couple of years in the past clinicians and researchers in dermatology began to discover the surface as a aim organ for many hormones. within the final years the outside has been famous because the greatest endocrine, paracrine and autocrine organ of the physique. it may metabolize steroid hormones and to supply derivatives with almost certainly systemic task. problems of hormone metabolism can both result in direct results at the dermis or in some way disturb dermis homeostasis. Endocrine dermatology is a brand new and fascinating zone of dermis study. It comprises pores and skin ailments because of or linked to endocrine issues, pores and skin issues that are taken care of with hormones or with compounds with hormone-like task, and pores and skin problems which take place as opposed occasions of hormone therapy or of remedy with compounds showing a hormone-like impression.
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Additional info for Basic Research in Endocrine Dermatology: 3rd Teupitzer Colloquium, Berlin, September 17-20, 2000 (Special Issue: Hormone Research 2000, 5-6)
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14 Messenger AG: The control of hair growth: An overview. J Invest Dermatol 1993;101:4S–9S. 15 Zouboulis CC, Akamatsu H, Stephanek K, Orfanos CE: Androgens affect the activity of human sebocytes in culture in a manner dependent on the localization of the sebaceous glands and their effect is antagonized by spironolactone. Skin Pharmacol 1994;7:33–40. 16 Sawaya ME: Purification of androgen receptors in human sebocytes and hair. J Invest Dermatol 1992;98:92S–96S. 17 Imperato-McGinley J, Gautier T, Cai L-Q, Yee B, Epstein J, Pochi P: The androgen control of sebum production.
Proc Natl Acad Sci 1991;88:10885– 10889. Randall et al. Horm Res 2000;54:251–258 The SAHA Syndrome Constantin E. Orfanos YaeI D. Adler Christos C. Zouboulis Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany Key Words SAHA W Seborrhoea W Acne W Hirsutism W Androgenetic alopecia Abstract The presence of seborrhoea, acne, hirsutism and alopecia in women has first been summarized as SAHA syndrome in 1982 and can be associated with polycystic ovary syndrome, cystic mastitis, obesity and infertility.
Androgen Receptors in Cultured Dermal Papilla Cells from Follicles with Differing Responses to Androgens in vivo Investigations into the mechanism of androgen action in cultured dermal papilla cells from human follicles with various responses to androgens in vivo have revealed the same paradoxes in vitro as seen in vivo. Both androgenstimulated beard [25] and androgen-inhibited balding scalp [26] dermal papilla cells contained higher levels of high affinity, low capacity androgen receptors than control non-balding scalp.