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By A. M. Davison (Auth.)

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R e n o g r a p h y shows t h e delayed a p p e a r a n c e and a r e d u c e d peak of radioactivity o n t h e s t e n o t i c side. 4. Split function studies are n o w rarely p e r f o r m e d b u t t h e y d e m o n ­ strate t h e functional i m p a i r m e n t of t h e s t e n o t i c side. T w o tests are described: a. H o w a r d test; considered positive if t h e s t e n o t i c side d e m o n ­ strated a r e d u c t i o n in urine v o l u m e of at least 4 0 per cent c o u p l e d with a r e d u c t i o n in s o d i u m c o n c e n t r a t i o n of at least 15 per c e n t or a c o n c e n t r a t i o n of creatinine at least 5 0 per c e n t greater t h a n t h a t from t h e unaffected side.

4. v. b y rapid infusion (5 m i n . ) . 5. v. infusion. 6. m. n. It is best t o b e c o m e familiar w i t h several of these drugs as n o t all cases will be c o n t r o l l e d by t h e use of o n e p r e p a r a t i o n . T h e prognosis in malignant h y p e r t e n s i o n is p o o r n o t only because of t h e underlying cause of t h e h y p e r t e n s i o n b u t because of t h e c o n s e q u e n c e s o n b l o o d vessels. Most p a t i e n t s die from either renal or cardiac failure.

5. Clofibrate has b e e n suggested as a t r e a t m e n t of t h e Upid abnormaUties b u t there is a high incidence of disabUng muscular compUcations. It m u s t be r e m e m b e r e d t h a t m a n y drugs are p r o t e i n b o u n d and so in h y p o p r o t e i n a e m i a aU m u s t be used w i t h c a u t i o n and dosage r e d u c t i o n con­ sidered otherwise t h e r e wiU be a high i n c i d e n c e of side effects. Causes of N e p h r o t i c produce nephrotic glomerular diseases, and the remainder S y n d r o m e .

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