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J. SINGER AND G. L. NICOLSON of normal cells, as predicted by the hypothesis rep­ resented in Fig. 7B. There has also appeared a study by Taylor et^ aJL (70) showing the remarkable effects produced on lymphocytes by the addition of antibodies directed to their surface immunoglobulin molecules. The antibodies induce a redistribution and pinocytosis of these surface immunoglobulins, so that within about 30 minutes at 37°C the surface immunoglobulins are completely swept out of the membrane. These effects do not occur, however, if the bivalent antibodies are replaced by their univalent Fab frag­ ments or if the antibody experiments are carried out at 0°C instead of 37°C.

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I. , Academic Press, New York (1971), p. 145. M. Glaser, H. J. Singer, M. I. Chan, Proc. Nat. Acad. Sci. S. 65:721 (1970). J. J. Singer, Ibid. 5^:1828 (1966). H. H. , p. 1552. W. Kauzmann, Advan. Protein Chem. 14:1 (1959). C. Tanford, J. Amer. Chem. Soc. 5474240 (1962). D. Korn, Annu. Rev. Btochem. 38:263 (19691. T. Marchesi and E. , Science 159: 203 (1968). 40 MEMBRANES AND VIRUSES IN IMMUNOPATHOLOGY 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. H. O. E. Green, Proc. Nat. Acad.

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