By Maurice Landy, Werner Braun
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Extra info for Immunological Tolerance. A Reassessment of Mechanisms of the Immune Response
Example text
Sterzl and Sercarz, respectively. We take into account the complex mosaic of antigens on sRBC. If, for example, this involved only 4 major antigenic groupings A, B, C, and D, tolerance could be induced to the major antigen A, even after injection of only a relatively small amount. It may take 3 or 4 injections or more before tolerance is in duced to antigen B. Meanwhile, antibody-forming cells speci fic for Β may appear even though the mice are already toler ant to antigen A. Additional injection of sRBC, increasing 33 IMMUNOLOGICAL TOLERANCE the concentration of antigen B, may result in tolerance.
DR. HOWARD: Aside from the experimental evidence, you are telling us that the cell can produce antibody without di viding. I think I would like to come to a more basic dis cussion. " After all, what we mean is that a cell that will not divide can get a sig nal and start to produce something that it was not producing before. If you call this differentiation, this is up to you. Anyhow, this situation is quite common. In the animal the action of a hormone on a target organ is an example of a signal starting production in a quiescent cell.
There one finds that in the preleukemic stages almost every thymus cell's phenotype is altered. If one looks later, after 6-8 months, however, one cell, or per haps 2 or 3 seem to have become favored. Thus one sees a clonal population of tumor cells. If you were to look only at the later time, you would draw the erroneous conclusion that clonal proliferation is the explanation of tumorogenesis. The other illustration goes back to the test system of organ versus cell culture which has already been mentioned by Dr.