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By Francois Guizot

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Thus, our method would overlook duplicated genes that result from the FSGD and that are retained in only one teleost genome. While we cannot exclude this possibility, we note that our observations are consistent with a genome-wide study of Tetraodon, in which Jaillon et al. (2004) showed that up to 3 percent of duplicated genes may have been retained since the FSGD event. One plausible explanation of the difference in duplicated gene retention between teleost and yeast may come from the different ages of the genome duplication event.

London, Vol. 131, pp. 289-304 Mayer, E. (1942). Systematics and the Origin of Species. A Correlation of the Evidence and Points of View of Systematics WithThose of Other Biological Disciplines, Particularly Genetics and Ecology. Columbia University Press, New York Nowak, M. ; Bonhoeffer, S. & May, R. M. (1994). Spacial Games and the Maintenance of Cooperation. Proc. Natl. Acad. Sci. USA, Vol. 91, pp. 4877-4881 A Theoretical Scheme of the Large-Scale Evolution by Generating New Genes from Gene Duplication 25 Ogden, G.

6b (Felsenstein 2004). Previous studies show that duplicated genes in yeast often diverge asymmetrically (Kellis et al. 2004), meaning that one copy evolves significantly faster than the other. We asked whether this is also the case for teleost duplicates. To this end, we compared evolutionary distances of duplicated genes with their human orthologs within the 1,500 gene families we had identified. There is indeed evidence for asymmetric evolution between duplicated gene pairs from the FSGD event (Table 2).

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