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1965) Overt 'mediating' behavior during temporally spaced responding. J. Exp. Anal. Behav. 8, 107-116. LeFever, F. (1973) Instrumental Response Chains and Timing Behavior. Unpublished doctoral dissertation, New York University, New York. Mechner, F. (1958) Probability relations within response sequences under ratio reinforcement. J. Exp. Anal. Behav. 1, 109-221. , Guevrekian, L. and Mechner, V. (1963) A fixed interval schedule in which the interval is initiated by a response. J. Exp. Anal. Behav.

Drug action depends critically on drug concentrations in the blood stream. Consequently, larger subjects with more fat may have more of the drug in fat, and less in blood, than do smaller subjects. To deal with this potential problem, drugs usually are given on a per-unit-body-weight basis. Most commonly, drugs are administered on a mg/kg basis. For drugs that do not have lipid affinity, adjusting for body weight is probably not crucial; most drugs of behavioral interest exert their actions on nervous tissue, and the amount of nervous tissue available is not highly correlated with total body weight (cf.

Skinner and his colleagues were developing procedures that allowed one to maintain the same temporal organization of behavior in individual organisms over extended periods (cf. Ferster and Skinner, 1957). Specifically, by controlling the experimental environment in which the activity of interest was free to occur at any time, Skinner and his associates were able to bring a degree of precision to the control of behavior that had not been achieved using more traditional discrete-trial methods. Using these procedures, Dews began to conduct experiments that marked the beginning of Behavioral Pharmacology as an identifiable enterprise.

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