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Dumont and R. Ratouis, Therapie 2 2 , 129 (1967). 14. Drug R e s e a r c h R e p o r t s 10(35), 3 (August 30, 1967). 15. S. Livingston, C. Villamater and Y. 9 (1967). 16. S. Limngston, C. Villamater, Y. Sakata and L. L. Pauli, J. Am. Med. Assoc. 2p0, 204 (1967). 17. D. Toreva, Farmakol. Toksikol. 30, 301 (1967). 18. J. G. Millichap and R. 0. WinstonYNeurology 17, 162 (1967). 2. C. Hansch, A. R. Steward, - - - - - - - - D ep r e s sant s Chap. 3 Lun sfo r d 19. R. M. G e s l e r , C. E. Lintz and E.

10, 6 2 1 (1967). 28. G. M. Simpson, J. W. S. Angus and J. G. Edwards, Curr. Therap. , 9, 486 (1967). 29. D. LenKe, N. Brock and B. , 17, 317 (1967). 30. H. Berzewski and H. , 17, 329 (1967). 31. H. Freeman and M. R. Oktem, Curr. Therap. , 8-, 395 (1966). 32. G. M. Simpson, J. Iqbal and F. Iqbal, Curr. Therap. , 8, 4 4 7 (1966). 33. L. J. Hekimian, A. Floyd and S. , Therap. , 9, 17 (1967). 34. W. G. Case and K. Rickels, Curr. Therap. , 9, 4 7 7 (1967). 35. M. P. Bishop and D. M. Gallant, J. , 7 342 (1967).

In the dog a n d monkey it is somewhat less effective than m e p r o b a m a t e , zoxaaolamine o r chlormeaanone, a n d m u c h l e s s so than chlordiazepoxide o r diazepam. Unlike COOCH(CH3) m o s t m u s c l e r e l a x a n t s of t h i s type, i t i s a selective antagonist of strychnine-induced conS02NH2 vulsions; however, i t s h a r e s t h i s p r o p e r t y with metaxalone and to a l e s s e r extent with mephene(XV) sin. Benzodioxane d e r i v a t i v e s continue to b e studied f o r t h i s activity.

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