By Graham A. Jamieson, David Mason Robinson
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Extra resources for The Diversity of Membrane. Mammalian Cell Membranes, Volume 2
Example text
All transport occurs through the brush border membrane, which is specialized for digestion and absorption. Apart from the enzymes mentioned already, this membrane contains sucrase, maltase, isomaltase and lactase, invertase, trehalase (Eichholz, 1967, 1968; Fujita et al, 1972), and fatty acid binding protein (Kessler and Mishkin, 1973), while the basolateral ORGANIZATION OF THE PLASMA MEMBRANE 39 membranes do not contain sucrase, alkaline phosphatase or aminopeptidase + + activity, but do contain N a ,K -ATPase (Fujita et al, 1972; Douglas, Kerley and Isselbacher, 1972).
5. A number of similar observations have been made with wheat-germ agglutinin and Ricinus communis agglutinin. 6. Clustering of intramembranous particles has been observed to accompany the agglutination of mouse plasmacytoma cells by Con A (Benedetti, Dunia and Diawara, 1973) and the translateral movement both of intramembranous particles (Pinto da Silva, 1972; Tillack, Scott and Marchesi, 1972) and external sialic acid residues (Nicolson, 1973b) has been shown to follow trypsin treatment of erythrocyte membranes.
N G F , like insulin, appears to express its biological effect by first binding to a receptor on the surface of responsive cells, but insulin and N G F receptors do not cross-react (Banerjee et al, 1973).