Download Mental Reality (First Edition) by Galen Strawson PDF

By Galen Strawson

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Extra info for Mental Reality (First Edition)

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Iloperidone is available in tablets only and is dosed 12–24 mg daily. It is recommended that iloperidone be titrated slowly to reduce the incidence of treatment-emergent orthostatic hypotension. The slow initial titration may delay the onset of efficacy associated with a therapeutic dose level. Compared with placebo, the most commonly reported adverse reactions reported at dosages between 20 and 24 mg/day were dizziness (number needed to harm (NNH)= 8), dry mouth (NNH= 12), fatigue (NNH= 34), nasal congestion (NNH= 17), orthostatic hy- 14 THE EVIDENCE-BASED GUIDE TO ANTIPSYCHOTIC MEDICATIONS potension (NNH= 25), somnolence (NNH= 10), tachycardia (NNH= 10), and weight gain (NNH=13) (Citrome 2009).

These tricyclic compounds can be further classified into three subgroups: • Aliphatic phenothiazines are low-potency antipsychotics, such as chlorpromazine and triflupromazine, which are quite sedating and have substantial hypotensive and anticholinergic side effects. 10 THE EVIDENCE-BASED GUIDE TO ANTIPSYCHOTIC MEDICATIONS • Piperidine phenothiazines include thioridazine, which also causes sedation, hypotension, and anticholinergic side effects. Moreover, this medication is likely to prolong QTc interval substantially such that it now carries a “black-box” warning requiring mandatory electrocardiogram (ECG) monitoring.

Aripiprazole, asenapine, iloperidone, and paliperidone were not included because they were approved after the study started. The 231 patients who had TD at study entry were randomly assigned to only SGAs rather than to perphenazine. The most prominent finding of the CATIE study was the 74% all-cause discontinuation rate for all antipsychotic drugs studied. The time to discontinuation was significantly longer for olanzapine than for risperidone and quetiapine. The differences between olanzapine and either perphenazine or ziprasidone were no longer significant after adjustment for multiple comparisons, possibly because of lower sample sizes for the latter two agents.

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