By Carlo C. Maley, Mel Greaves
This is the fitting publication for someone considering beginning a occupation in, or moving their profession to, learning the dynamics that force melanoma development and its reaction to treatment. themes contain the speculation and inhabitants genetics of cancers, genetic range inside tumors (intra-tumor heterogeneity), figuring out how mutant clones extend in tissues, the position of melanoma stem cells within the dynamics of tumors, the evolution of metastasis, and the way to enhance melanoma remedy by way of addressing the evolution of cancers in accordance with our interventions. There also are chapters at the styles of melanoma susceptibility in people because of a mismatch among our glossy surroundings and the surroundings within which our ancestors developed, in addition to a bankruptcy at the evolution of melanoma suppression mechanisms that experience developed in several species, quite the big long-lived animals like elephants and whales which are greater at suppressing cancers than people.
This ebook serves as a primer at the evolutionary and ecological concept of melanoma- the framework upon which the entire info of melanoma could be hung. it truly is excellent for oncologists and melanoma researchers attracted to evolutionary conception, and evolutionary biologists and ecologists attracted to gaining insights into melanoma improvement and prevention.
Read or Download Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions PDF
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Extra info for Frontiers in Cancer Research: Evolutionary Foundations, Revolutionary Directions
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Nature 469(7330):356–362 43. Hirsch D, Camps J et al (2012) A new whole genome amplification method for studying clonal evolution patterns in malignant colorectal polyps. Genes Chromosomes Cancer 51(5):490–500 44. Masuda M, Toh S et al (2013) Somatic evolution of head and neck cancer - biological robustness and latent vulnerability. Mol Oncol 7(1):14–28 45. Kemp CJ (2005) Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin Cancer Biol 15(6):460–473 46. Taylor TB, Johnson LJ et al (2012) First steps in experimental cancer evolution.
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The hierarchical cellular structure of malignancies is therefore another fundamental mechanism that needs to be taken into consideration -- it has remarkable effects on the evolutionary dynamics of the tumor [38, 57]. 4. Intra-tumor heterogeneity. Tumors are not a homogeneous population of cells but rather a mixture of sub-clones with different phenotypic and genotypic characteristics. Such variation is an important feature of tumors and it is responsible for the failure of therapy and the development of treatment resistance [7].