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Extra resources for Defense Against Bioterror: Detection Technologies, Implementation Strategies and Commercial Opportunities--Proceedings of the NATO Advanced Research Workshop on Defense against Bioterror held in Madrid, Spain from 8 to 11 April 2004 (NATO Security through
However the toxin is unable to cross the blood-brain barrier to influence brain cholinesterase activity. In addition to respiratory difficulty, NATURAL TOXINS: THE PAST AND THE PRESENT 39 anatoxin-a(S) unlike anatoxin-a, induces hypersalivation in mammals as well as other symptoms more typical of neurotoxicity such as diarrhea, tremors and nasal mucus discharge. 7. MYCOTOXINS Mycotoxins are low molecular weight secondary metabolites of mould or fungi [30-32]. These compounds are non-volatile and may be sequestered in spores or secreted into the growth substrate.
The remote care capability reduces the likelihood of the dissemination of disease to physicians and communities in which the physicians reside. A telemedicine system would also retain health care delivery in communities providing health care back-fill. 7 STRATEGIC NET-CENTRIC BIOLOGICAL DEFENSE SYSTEM Networked Operations at the Coordinating Level and Lower Echelons of Command A decision making component is required for coordinating the delivery of actionable information. Figure 1 illustrates such a flow chart.
Saxitoxin itself is highly toxic. It is toxic by ingestion and by inhalation, with inhalation leading to rapid respiratory collapse and death. 36 NATURAL TOXINS: THE PAST AND THE PRESENT Figure 5; Chemical structure of saxitotin (STX) and five saxitoxin derivatives. Saxitoxin exerts it’s toxic effect by interfering with the transmission of signals through the nervous system. The toxin binds specifically to the voltage-gated sodium ion channels and prevents their normal function. This blocks the creation of a proper action potential and the nerve cell no longer has the means to transmit a signal.