By Uwe Reinhold, Wolfgang Tilgen
The decade has obvious a renaissance of the concept that of individualized chemotherapy in oncology, markedly encouraged via the improvement of latest in vitro chemosensitivity assays. The scientific application of drug reaction assays has been evaluated in medical trials and the consequences recommend that assay-assisted treatment choice could enhance survival in addition to financial results. This quantity contains the lawsuits of the 1st Symposium of the foreign Society for Chemosensitivity trying out in Oncology, ISCO-1, held in Homburg/Saar, Germany, in September 2001. the subjects comprise: new in vitro drug-testing equipment, tumor chemosensitivity assays, and the scientific relevance of assay-directed remedy.
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B. C . C . S G D G S transparent zone for microscopy • thin film O2- sensor • temperature sensor • IDES: impedance cell culture area (membrane properties, cellular contacts) D IDES (impedance) Fig. 1. Schematic view of (A) a silicon chip and (B) a glass chip systemic individuality of each organism cast great uncertainty on such predictions. Unnecessary chemotherapeutic treatment, which means distress and valuable time lost for pursuing other promising treatments, could be avoided if at least the resistance of the patient s tumor for a drug or drug combination could be tested before deciding on the treatment.
Cancer Detect Prev 22:305–312 9. Sargent J, Elgie A, Williamson C, Taylor C (1997) The use of the MTT assay to study drug resistance in acute myeloid leukaemia – an update. Adv Blood Dis 3:33–41 10. Taylor CG, Sargent JM, Elgie AW, Williamson CJ, Lewandowicz GM, Chappatte O, Hill JG (2001) Chemosensitivity testing predicts survival in ovarian cancer. Eur J Gynaecol Oncol 22:278–282 11. Gontero P, Sargent JM, Hopster DJ, Lewandowicz GM, Taylor CG, Elgie AW, Williamson CJ, Sriprasad SI, Muir GH In vitro chemosensitivity to mitomycin C in transitional cell carcinoma of the bladder and its relationship with P-glycoprotein and apoptotic factors.
The chips, associated growth chambers, and tubing can be sterilized with sodium hypochlorite. An important feature of the test system is that the cells are perfused with culture medium, thereby ensuring a continuous supply of nutrients while metabolic waste products are removed. Adherent tumor cell lines LS174T as well as S180 and its doxorubicin-resistant counterpart were used. Cells were trypsinized, seeded on to the chips at 2–4103 cells/mm2, and precultured under standard conditions in medium (RPMI) with 10% FCS.