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Defined heparin oligosaccharides are likely to become active agents not only in heart disease but also in cancer and other diseases. Glycolipid-based signalling processes will probably be exploited for therapeutic intervention in metabolic disease and for new immunomodulators. Eventually, synthetic biology should be able to supplement chemical efforts to create large quantities of defined carbohydrates for therapeutic and diagnostic applications. And no doubt new biological roles of carbohydrates will be discovered that surpass our wildest speculations.
For example, most silicon electronic circuits are produced by the deposition of various oxide and metallic layers, whereas the structures used by Kuo et al. are produced by crystal growth. The authors are confident that their different fabrication process is suitable for mass production. Let’s hope they are right. ■ Gareth Parry is in the Department of Physics, Imperial College London, Prince Consort Road, London SW7 2AZ, UK. uk 1. , Kapur, P. & Saraswat, K. C. J. Lightwave Technol. 22, 2021–2033 (2004).
Nature 419, 638–641 (2002). 9. Veaute, X. et al. EMBO J. 24, 180–189 (2005). 1245 NEWS & VIEWS NATURE|Vol 437|27 October 2005 MATERIALS SCIENCE Changing face of the chameleon a I A. Lindsay Greer and Neil Mathur Chalcogenide materials form the basis of CD and DVD technologies. But an identity crisis looms in the wider field: what role do atomic reconfiguration, electronic processes and ionic movement play in these materials? The chalcogens — the elements in group VI of the periodic table, particularly sulphur (S), selenium (Se) and tellurium (Te) — react with more electropositive elements, such as silver, to form chalcogenides.