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Extra resources for Nature (Vol. 431, No. 7008, 30 September 2004)
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1b–d (and Supplementary Movies 1 and 2) shows that at 0 s (no cell–cell contact) Ca2þ levels were low and both TCRb and IFNGR1 were uniformly distributed in the cell ©2004 Nature Publishing Group 527 articles membrane. Immediately after Ca2þ influx, both IFNGR1 and TCRb on the naive T cell progressively migrate to the contact interface with the dendritic cell (Fig. 1b, c). Restricted co-polarization of IFNGR and IL-2R cytokine receptors with the TCR at the immunological synapse We obtained similar results when Thp activation was induced by crosslinking of TCR at 37 8C with a secondary antibody in the absence of dendritic cells.
21. Woosley, S. E. & Weaver, T. A. The evolution and explosion of massive stars.
Guerra*, Peter M. Atkinson†, Simon I. uk †School of Geography, University of Southampton, Highfield, Southampton SO17 1BJ, UK ‡Public Health Group, KEMRI/Wellcome Trust Research Laboratories, PO Box 43640, 00100 GPO, Nairobi, Kenya 1. Holden, C. Science 305, 639–640 (2004). 2. Whipp, B. J. & Ward, S. A. Nature 355, 25 (1992). 3. Rendell, M. ) The Olympics: Athens to Athens 1896–2004 338–340 (Weidenfeld and Nicolson, London, 2003). 4. Gilks, W. , Thomas, A. & Spiegelhalter, D. J. Statistician 43, 169–178 (1994).