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Extra resources for The New England Journal of Medicine - Nov 10, 2011 - Vol. 365 No. 19

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26. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetyl­ cysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7. 27. Neuschwander-Tetri BA, Bellezzo JM, Britton RS, Bacon BR, Fox ES. Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells. Biochem J 1996; 320:1005-10. 28. Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M.

07) (Fig. 2). 14). 06). ated with mortality in a univariate analysis (Table 3). 02); a Cox model for multivariate analysis. 30). 001). org. The difference was significant only on day 14 (160 μmol per liter in the prednisolone-only group vs. 003) (Table 1S in the Supplementary Appendix). For the whole study population, data on the bilirubin level on day 7 were available for 159 patients (2 patients had died, and data were missing for 13 other patients). A bilirubin decrease on day 7 was observed in 128 patients (81%).

Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 1998;115:443-51. 14. Bird GL, Sheron N, Goka AK, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 1990;112:917-20. 15. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992; 16:1423-7.

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