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By James Morrow

Jennet Stearne's father hangs witches for a residing in recovery England. but if she witnesses the unjust and frightening execution of her cherished aunt Isobel, the precocious baby makes a decision to make it her life's venture to deliver down the Parliamentary Witchcraft Act. Armed with little keep the facility of cause, and decided to work out justice be triumphant, Jennet hurls herself right into a sequence of picaresque adventures—traveling from King William's Britain to the fledgling American Colonies to an uncharted island within the Caribbean, braving West Indies pirates, Algonquin Indian captors, the machinations of the Salem Witch courtroom, and the sensuous love of a tender Ben Franklin. For Jennet can't and mustn't ever relaxation till she has positioned the final witchfinder into bankruptcy.

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26. Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetyl­ cysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989;6:593-7. 27. Neuschwander-Tetri BA, Bellezzo JM, Britton RS, Bacon BR, Fox ES. Thiol regulation of endotoxin-induced release of tumour necrosis factor alpha from isolated rat Kupffer cells. Biochem J 1996; 320:1005-10. 28. Verhasselt V, Vanden Berghe W, Vanderheyde N, Willems F, Haegeman G, Goldman M.

07) (Fig. 2). 14). 06). ated with mortality in a univariate analysis (Table 3). 02); a Cox model for multivariate analysis. 30). 001). org. The difference was significant only on day 14 (160 μmol per liter in the prednisolone-only group vs. 003) (Table 1S in the Supplementary Appendix). For the whole study population, data on the bilirubin level on day 7 were available for 159 patients (2 patients had died, and data were missing for 13 other patients). A bilirubin decrease on day 7 was observed in 128 patients (81%).

Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 1998;115:443-51. 14. Bird GL, Sheron N, Goka AK, Alexander GJ, Williams RS. Increased plasma tumor necrosis factor in severe alcoholic hepatitis. Ann Intern Med 1990;112:917-20. 15. Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC. Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 1992; 16:1423-7.

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