By Warwick L. Morison
With a better emphasis at the uncomplicated rules, functional ideas, and economics of phototherapy, the 3rd version continues to be the traditional resource at the UV therapy of pores and skin disease-presenting an elevated variety of case reviews, medical options, and remedy protocols for a transparent realizing of the current and destiny country of phototherapy, photochemotherapy, and phototesting within the dermatologic enviornment.
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Additional resources for Phototherapy and Photochemotherapy for Skin Disease, Third Edition (Basic and Clinical Dermatology)
Sample text
THE NEUROENDOCRINE SYSTEM Light and the absence of light have a marked effect on many bodily functions. Light reaching the retina activates a neural pathway to the pineal gland, which regulates production of substances that influence the functions of the brain and endocrine organs. The hormone melatonin is one product of the pineal gland, and has been the most investigated because it is readily assayed in blood and urine. Secretion of melatonin is maximal in the dark and is suppressed by exposure to bright light.
It is very important Table 1 Grades of Erythema Abbreviation Description 0 Æ þ 2þ 3þ 4þ No reaction Faint erythema, indefinite borders Minimal erythema dose, pink Red erythema Fiery red with edema Violaceous with vesiculation 26 Morison Figure 3 The erythema action spectrum. , first-, second-, and third-degree burns. Thermal burns scar, whereas erythema is a self-healing process. Many factors influence the development of erythema and a few important ones will be considered. The Wavelength of Radiation The UVB waveband is the most biologically active portion of the solar spectrum, and that waveband is responsible for most of the erythema seen following exposure to sunlight (Fig.
The factors that determine such variation are largely unknown. The presence of photosensitizing agents such as drugs, dietary constituents, and topically applied substances must always be considered when evaluating normal, or possibly abnormal, responses to radiation. Prior Exposure to Radiation An important axiom in photomedicine is that the skin never forgets. Although at the end of winter the back skin and buttock skin of a fairskinned adult may appear to be the same white color, the buttock skin and breast skin in women, if never previously exposed to radiation, will have a significantly lower threshold response to UV radiation.