By Matthew Kaufman, Alexander Yu. Nikitin, John P. Sundberg
Rework Your laptop computer screen right into a digital Microscope The world’s best professional on mouse embryology, Dr. Matthew Kaufman is liable for generating vintage texts which are thought of the main revered within the box. whereas the standard in their photowork on the time used to be thought of cutting-edge, the expertise on hand whilst the books have been produced constrained the unique published pages to black-and-white photomicrographs and line diagrams, that are too small and never certain sufficient to satisfy the necessities of today’s mouse pathologists who call for excessive answer, excessive precise complete colour slides. assembly this desire and going past, Histologic foundation of Mouse Endocrine process Development:A Comparative research not just bargains upgraded slides yet really turns your laptop right into a digital microscope that researchers from quite a few brief years in the past can have simply dreamt approximately. operating along with Dr. Nikitin and Dr. Sundberg, Dr. Kaufman has scanned the best photographs from his prior collections after which utilizing smooth picture know-how has increased the standard to degrees no longer visible prior to. by means of fitting the ImageScope™ software program (Aperio applied sciences, Inc.) and snap shots from the accompanying DVD, readers should be in a position to flip their desktops into digital microscopes. working their pcs like state-of-the-art diagnostic instruments, they could stream the picture from the glass microscope around the monitor and magnify parts of curiosity for extra distinctive assessment. This software permits them to examine particular organs or constructions at numerous magnifications at assorted levels of embryogenesis, assisting to spot constructions in common mouse embryos and supplying a comparability for these embryos less than research. whereas the emphasis of this exclusive publication is on comparative embryology of the endocrine organs, the embryonic pictures at numerous developmental phases include many different organs. It offers a chain of consultant figures that exhibit the histological gains of hematoxylin- and eosin-stained sections of many of the endocrine organs at sequential levels in their improvement within the mouse.
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Additional info for Histologic Basis of Mouse Endocrine System Development: A Comparative Analysis (Research Methods for Mutant Mice)
Sample text
However, in the inner fasciculata, the nuclear population was increased during the summer due to a significant increase in nuclear density and width of this zone. It was suggested that the increase in the nuclear population during the summer in the zona glomerulosa might be related to an increase in sodium-retaining hormones that could account for the increase in water retention observed at that time of the year. No explanation was proposed for the increase in the nuclear population in the inner part of the zona fasciculata in the summer.
In the male mouse, this zone is said to soon The Adrenal (Suprarenal) Gland 27 cease growing, and entirely disappears by the time of puberty. In the female, this zone continues to grow until 4–5 weeks after birth, by which time it occupies a large proportion of the total volume of the gland. This zone is eventually replaced by fatty infiltration. In the virgin female it may remain until the female is three months of age, while in the pregnant female it rapidly involutes. Howard-Miller83 first recognized the X-zone in the mouse at about 3 weeks of age, and its degeneration in male mice was noted at 5 weeks of age.
It has now been established that acetylcholine is the immediate physiological stimulus that causes the chromaffin cells to release their catecholamine hormones, by acting on the outer surface of these cells,88 possibly by promoting the inward movement of calcium across the cell membrane. 28 Histologic Basis of Mouse Endocrine System Development The catecholamines are usually present in high levels in the medullary tissues. 15,89 The release of one or more hormones from the medulla appears to depend on the nature of the activating stimulus.